Is this video card compatible with my mother board?

[Rob64]

I have a MSI 760GM-P34 motherboard and I want to change out my current video card with the Sapphire Nitro Radeon R9 390 video card, will this motherboard and video card combo work?

 

[RCFProd]

Yes, any modern motherboard will work actually. They all have a PCIE X16 slot. The 760GM-P34 is not great though but that is more about VRM cooling than compability.