Will my MSI H81M-E33 have compatibility issues?

Ahoo

Reputable
Sep 3, 2015
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I'm planning to buy a new GPU. I want to buy a GTX 970 for my R9 380 2GB. I currently have these specs.

Mobo: H81M-E33
CPU: i5-4460
RAM: 2x4GB 1600MHz DDR3
Hard Drive: 2TB 7200RPM with 120GB SSD
PSU: 600W

If I buy a 970 and replace it with my R9 380, will it have compatibility issues with my motherboard, since it only has PCI 2.0 and it is a microATX?