Multi rail will do just fine. The advantages of single vs multiple rails are a myth. The problem was never about a problem with single versus multiple rails but simply of a specific bonehead design of a particular multiple rail design
http://www.jonnyguru.com/forums/showthread.php?t=3990
Why do some people FUD that single is better?
Because there are a few examples of companies that have produced power supplies with four +12V rails, something that in theory should provide MORE than ample power to a high end gaming rig, and screwed up. These PSU companies followed EPS12V specifications, which is for servers, not "gamers". they put ALL of the PCIe connectors on one of the +12V rails instead of a separate +12V rail. The +12V rail was easily overloaded and caused the PSU to shut down. Instead of correcting the problem, they just did away with the splitting of +12V rails altogether. Multiple +12V rail "enthusiast" PSU's today have a +12V rail just for PCIe connectors or may even split four or six PCIe connectors up across two different +12V rails. The rails themselves are capable of far more power output than any PCIe graphics card would ever need. In fact, Nvidia SLI certification these days REQUIRE that the PCIe connectors be on their own +12V rail to avoid any problems from running high end graphics cards on split +12V rail PSU's.
There's less components and less engineering to make a PSU that DOES NOT have the +12V rail split up, so it's cheaper to manufacturer (about $1.50 less on the BOM, $2 to $3 at retail) and typically this cost savings is NOT handed down to the consumer, so it actually behooves marketing to convince you that you only need single +12V rails.
Multiple rails will only be a problem if say a manufacturer decide to put all PCIE cable on just oine of the rails or a user reads on a forum that it is OK to use Molex to PCIE adapters and overloads one of the rails. That just "isn't done" outside of a bonehead manufacturer
As for power consumption, the 280c can hit peaks well above 300 watts.
Note that from a power supply standpoint that doesn't necessarily mean you have to account for 350 watts of load for the purposes of PSU selection. That's what capacitors are for. Also, that's using Furmark, gaming is about 100 watts less (247).....add 10% for overclocking.
However wide load swings can cause short voltage fluctuations and if you are looking for that last 10 MHz on your overclock, you might get tripped up. For 95% over Afterburner users, the difference is not worth noting.
http://www.tomshardware.com/reviews/power-supplies-101,4193-24.html
The average power draw under load over a certain period of time, as well as the power consumption of the rest of the system, are the only measurements that are really important in PSU selection, not the brief spikes. You've hit the ideal power range if the sum of all components amounts to approximately 75 percent of the maximum capacity during a stress test.
Of course, when you use the 75% figure and average consumption .... versus the brief spikes and 100% , you will very often get answers very close to one another.