It will probably run, but I'd want a larger capacity unit for the GTX 780. Minimum recommended capacity is 575w so you're below recommended spec, but it's a decent unit and may be ok. I'd suggest you could use it for now, but plan to upgrade to a larger PSU, 600w or higher, in the near future. The EVGA B2 750w or Seasonic S12II 620w would both work fine.