Yes
but there are caveates naturally because it all depends on how the disk was formatted. MACs use HSF/HSF+ natively and of course Windows can't read that format natively, they are FAT/NTFS/GPT based.
If the drive is partitioned in MAC format then you will need to install a program that can read the drive in Windows like HSF Explorer.
Or you could copy everything off of the drive and back into the MAC. Reformat the drive to something both can read, such as FAT32 or exFAT, and then copy the files back.
*exfat supports files larger then the 4GB limit of FAT32.