I have never used My Documents nor allowed the OS to install things in ProgramFiles....Since 1993, we have never had anything else on C:\ but the OS.
1. Make a small D:\Partition on the HD (say 64 GB) so that page and temp files are on the outer edge of the drive where performance is fastest. Move the page files and temp files to a partition on D:\
Windows 7
-Control Panel / System / Advanced System Settings / Advanced tab / Perfomance SETTINGS / Advanced / Change...... Set C to 0; set D to Min and Max of 16396 MB
-Control Panel / System / Advanced System Settings / Advanced tab / ENVIRONMENT VARIABLES / Top Window
Select TEMP / EDIT / Change to D:\Temp
Select TMP / EDIT / Change to D:\Temp
The rest you can create partitions any way ya want. Some people put everything in "one drawer", others want to have the equivalent of a "socks drawer", "pants drawer, "shirts drawer" if ya get my meaning.
When you install programs, select custom install and change from C:\Program Files\ Adobe to say E:\Adobe
Game files, data files, email files are all the same, just tell the system where you want to install them when ya hit "save as"