Depends if its a decent quality unit & what CPU you're running.
The 380 is a 180w GPU , you really want a 12v rail with s minimum ampage of 32a even if you're running a sub 90w i3 or i5.
Without actual PSU specs its impossible to say - I would hazard a guess that its not great idea though , any 500w should come with a minimum of 2x6 pin connectors , if it doesn't it normally means they're not up to the job.