well the moterboard does not really matter much, so yeah, might as well go for it if you have a decent 400W or better PSU. Asus GPU tweak is okay, ( use it with Asus cards) Also a software that seems to work well on every card is MSI afterburner. take overclocking slow, go 10 MHz, then stress it, +10 MHz, stress... etc... If you have the time go by 5 MHz. once myou have found the max for the core, put it to stock and try the memory. then once you have found its max, set them both to stock, and increase them each 5 MHz at a time. Add voltage as needed ( and if you have voltage control), but generally you will notice how all the sudden it takes a voltage boost every clock increasing, and that is where you should probably stop. Always watch the temps.