As a secondary drive it is possible:
http://www.seagate.com/ca/en/support/downloads/beyond-2tb/
(under "data disk" the extended capacity download needs to be installed)
I don't know enough to confirm there won't be any issues due to driver support.
Western Digital and others likely have similar tools.
Just FYI, but I took an old XP computer that was sluggish and had issues, wiped the drive and put on Linux Mint 32-bit. It runs really great now for the internet, and it has Libre Office and a couple other applications I put on. I then reinstalled it again on an old 60GB SSD I had laying around and it works even better.
I also later put in a spare HD5450 graphics card which helped with some video (CPU was really weak for playing video so the GPU's video decoder could help in some situations by quite a bit).
(X2-3800+ CPU and 1GB system memory)