2GB is low, but assuming you're at 1080P you shouldn't have to drop settings down too far, I wouldn't have thought.
Here's some suggestions for lowering VRAM in GTAV specifically for 2GB cards: http://greengamers.com/gta-5-pc-best-graphic-settings-to-reduce-vram-and-increase-performance/
Specific settings like AA can make a massive difference to VRAM usage. That guide about also talks about lowering character variety (but not the number of characters), helps significantly.
For sure you'll have to make compromises with demanding games, but I suspect with most games there will be few particular settings that are chewing up significant amounts of VRAM. If you can find those and drop them down, you can probably leave the rest of the detail sliders at higher levels, rather than just having to drop everything down to low.