Yes, you'll be fine. You should know that all current motherboards that have a PCIe (3.0) 16x slot are compatible with all the graphics cards. The only problem that you may face is if you have a very small case and a very big graphics card and this card is not very big. Also you should make sure that your power supply has the required capacity and the necessary cables in order to properly support your graphics card. You should be fine if you have a quality 450+ watt PSU. Good luck.