Is the alienware x51 r2 motherboard compatible with this case?

Kappa909

Commendable
May 15, 2016
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This is the case :https://www.amazon.co.uk/gp/product/B017XPP9KK/ref=ox_sc_sfl_title_3?ie=UTF8&psc=1&smid=A3P5ROKL5A1OLE

And does it matter that it wont have an IO shield because the one for this motherboard is built into the alienware case and is irremovable?