Yes you should have no problems with that setup! I used a TR2 Thermaltake 600wt with a PNY XLR8 Nvidia Gtx470 gpu and the gpu was FERMI based with 2 6pin power connectors at 350watts/95c temps! Yipes! Ran for 2 yrs no problems with the Thermaltake TR2 600wt psu! The 650ti needs at least 400wt and 20amps on the single 12v 6pin rail. Good Luck!