Your motherboard won't be the limiting factor here; it has a full PCIe 3.0 x16 slot so it can accept any card on the market. The real issue is the power supply; I don't know which specific model it is but I have to assume for safety's sake that it lacks a PCIe 6-pin connector; in that case, the most powerful card you should use is the special GTX 950 with no 6-pin connector; these aren't widely available everywhere and if you can get that R7 250 (I assume it's this one? http://www.newegg.com/Product/Product.aspx?Item=N82E16814202052) for a good price, then go for it. Keep in mind that the 250 is a PCIe 3.0 x8 card internally, and your CPU only supports PCIe 2.0, so the card will run at PCIe 2.0 x8; not a big deal for gaming, but just...