Yes. My original 1440p gaming system had a GTX660Ti. You can run 1440p. You'll just have to find the appropriate settings for each game. Start by turning down shadow detail, then some lighting effects. You may still have to turn water a little lower than you want and lighted particles in the air are fps eaters. With a 780, you should be able to leave most of this on high, with a few on the next level, whatever it's called in the game.