Whats your sound setup? I mean what cable are you using for sound, hdmi?
Digital display audio/Amd high definition audio is hdmi.
May i repeat the question what is your PC make/model please. It will help us help you.
My thought on the issue after 'cleaning memory' Windows 10 may have gone through a recovery process if something was corrupted and possibly now generic Windows drivers are being used.
Depending which device you're using for sound (not sure yet), if it is your AMD gpu, did you get drivers from AMD.com?