Best advice would be to go to AMD's site, and download/update your drivers for any of their devices that you're using to work with your operating system, from there. Drivers are often being updated by AMD as well as NV as time goes by. Unless the drivers on that disk are the latest, you'll likely be prompted to uninstall them, and install the latest ones after downloading them. Just make sure to read the details and follow their directions and you should have no problems. If you'd rather not use their latest drivers, it may be possible to obtain earlier versions and use those instead.
As for the realtek drivers, chances are if you have sound, and an internet connection on your system, hopefully you have the latest versions of them already.