raisonjohn :
I am already set to purchase 2 MSI GTX 1080 Gaming X GPU's for my 3x 1440p/60Hz (surround). I'll be getting the either the MSI X99A Godlike Gaming or the Asus Rampage V Edition 10 - with either a Haswell-E or Broadwell-E (most likely a 40-lane Haswell-E). So, no problems with mounting considerations and compatibility - unless such 2-way setup can't perform 50/60-ish fps... Aside from gaming, this rig is also to be used for 3d modeling/rendering.
The reason I am asking is I am very curious in the spec-for-spec differences of the other mobo's I was initially considering before (esp. the Z170's - when I was still considering a Skylake build). I was initially confused with all the x's and the /'s but was able to figure out how the spec notation works.
It'll be my 1st time to build a multi-GPU system.
X99 with a second grade chip should support 2 way in 16/16 and 3 way in 16x8x8 (and most will do 8x8x8x8 four way) unless they have PLX in which case you might see x16 all the way across the board (but effectively the same as the above), but not the 6800K and other bottom tier ones, they only have 28 lanes and therefore limited to 16/8 or 8x8x8.
In the case of standard Z level boards, the chip will be limited to 20 lanes, so you have either 8x8 or 16x4 (crossfire only) and no higher options.... UNLESS of course you have one of the PLX based boards in which case you could see 16x16 and 8x8x8 or higher (though most boards don't use it any more, too expensive to develop/build and far too few people buying them)