first make sure you have selected to apply changes to the led channel with the attached led's, next make sure you click "save changes" obvious but just checking, i would suggest removing all the channels and just put a single strip in each channel to test it, make sure everything has power, the connections for the cables running the power for the led's to the hue+ may be faulty. and if this doesnt work i would completely uninstall and reinstall, you can also try playing around with profiles. I get problems with the software and the lights every now and then as my pc gets moved around a lot