It depends on how much space you have really but the twin turbo was designed to fit a gpu near the bottom of the card, it will still work if the gpu is in a different position it just requires more space, my 760 with the gpu in the middle had about an extra inch in height and an extra 2 inches in length and I didn't use the backplate, instead I used individual heatsinks for the ram chips to get an extra 1ghz out of the ram.