Without an OS to load, you'll keep getting that "Insert Boot Media" screen. Once you know your drive is seen in the OS, then load up the OS. Plug in the USB with Windows 10 on it in to the computer. Turn on the computer. Start tapping the F12 key (check your manual, but it should be F12) to bring up the boot option menu. Select the USB drive and it should boot from there in to the install process.