Have you taken the time to look at drive mounts and seen that there are no 5.25" bays? This can be a deal breaker for some. However I see 5.25" drives as unnecessary and I don't currently have one in my build as I can put all that I need on USB devices. If needed, you can even get a USB optical drive... Many of which are bootable.
2.5" and 3.5" drives mount on anti vibration mounts behind the motherboard in that case.