2,500 US Dollar PC Build Help

How about this build (color theme: white).

PCPartPicker part list / Price breakdown by merchant

CPU: Intel Core i7-6700K 4.0GHz Quad-Core Processor ($324.95 @ Amazon)
CPU Cooler: NZXT Kraken X61 106.1 CFM Liquid CPU Cooler ($114.99 @ B&H)
Motherboard: MSI Z170A XPOWER GAMING TITANIUM EDITION ATX LGA1151 Motherboard ($259.99 @ Amazon)
Memory: Corsair Vengeance LPX 16GB (2 x 8GB) DDR4-3200 Memory ($86.92 @ NCIX US)
Memory: Corsair Vengeance LPX 16GB (2 x 8GB) DDR4-3200 Memory ($86.92 @ NCIX US)
Storage: Samsung 256GB M.2-2280 Solid State Drive ($188.01 @ Amazon)
Storage: Hitachi Deskstar 7K3000 3TB 3.5" 7200RPM Internal Hard Drive ($124.99 @ Newegg)
Video Card: MSI GeForce GTX 1080 8GB Video Card ($648.73 @ OutletPC)
Case: Phanteks Enthoo Evolv ATX Glass ATX Mid Tower Case ($189.99 @ Newegg)
Power Supply: SeaSonic Snow Silent 750W 80+ Platinum Certified Fully-Modular ATX Power Supply ($149.99 @ B&H)
Operating System: Microsoft Windows 10 Pro OEM 64-bit ($109.98 @ My Choice Software)
Total: $2285.46
Prices include shipping, taxes, and discounts when available
Generated by PCPartPicker 2016-10-09 23:28 EDT-0400

A little description too.

CPU
Put in the best LGA1151 socket Skylake CPU currently on the market. It has unlocked multiplier that fully supports overclocking.
specs: http://ark.intel.com/products/88195/Intel-Core-i7-6700K-Processor-8M-Cache-up-to-4_20-GHz

CPU cooler
NZXT x61 Kraken, the best AIO water cooling unit to cool down your CPU, even when running CPU in the overclocked mode. Only the custom made water loop is better than the Kraken.
specs: https://www.nzxt.com/products/kraken-x61

MoBo
Put in the high end MSI Z-series MoBo. Z-series MoBo enables you to fully overclock your CPU and RAM aswell. While the base RAM frequenzy is 2133 Mhz, this motherboard supports overclocking RAM speeds up to 3200 Mhz.
LGA1151 socket this MoBo has, supports the current Skylake and future Kaby Lake and Cannonlake CPUs from Intel.
The bells and whistles this MoBo has is so long that you're better reading them by yourself from the following link.
specs: https://www.msi.com/Motherboard/Z170A-XPOWER-GAMING-TITANIUM-EDITION.html

RAM
Put in two sets of 2x 8GB RAM, total of 32GB. This RAM supports overclocking speeds up to 3200 Mhz. Also the white aluminium heat spreaders on the RAM sticks is a great fit to the white surroundings.
specs: http://www.corsair.com/en/vengeance-lpx-16gb-2x8gb-ddr4-dram-3200mhz-c16-memory-kit-white-cmk16gx4m2b3200c16w

Storage
Put in a M.2 NVMe SSD for ultra fast read/write speeds with plenty of space for the OS, total of 256GB.
specs: http://www.samsung.com/semiconductor/products/flash-storage/client-ssd/MZVPV256HDGL?ia=831

And for file storage, a reliable 3TB HDD from HGST.
specs: https://www.hgst.com/sites/default/files/resources/DS7K3000_ds.pdf

GPU
MSI version of GTX 1080 with a classy black & white theme, second best GPU on the market. Best being Titan X Pascal.
specs: https://www.msi.com/Graphics-card/GeForce-GTX-1080-ARMOR-8G-OC.html

Case
Picked the case you desired but changed the color to Galaxy Silver to complete the white theme for this build.
specs: http://www.phanteks.com/Enthoo-Evolv-ATX-TemperedGlass.html

PSU
Put in a great 80+ Platinum PSU from Seasonic. It has white color theme which fits perfectly with the overall theme of the build.
specs: https://seasonic.com/product/snow-silent-750/

OS
Windows 10 Pro 64 bit to run the whole system.
info: https://www.microsoft.com/en-us/windows/features

Also left you plenty of free money for putting it towards your AMD Vega.