specify the part number, the CPU memory controller will run at the slowest SPD speed (MHz) and timing (latency), for example a DDR3 1600 CL 10 pair with DDR3 1600 CL9 then you must set both of them at exact speed and timing such as 1600 CL 10 RAS 15 ..., there's a good chance if both of them will cause no problem if they are same chip model (samsung, hynix, micron) model (Micron D9LCK, Hynix H5TQ2G83BFR-H9C, etc).