Custom water loop radiator size

Solution
You dont need to separate loops one is just fine. You will need a 240mm for the cpu at a minimum and then 120 for the 1080. Order of the loop doesnt mater, after about 20-30min of gaming your water temps will stabilize, its more of flow that your going to be concerned about. You dont want to go from the bottom of the case to the top back to the bottom multiple times.

Depending on your case layout i would go res-> pump-> 240-> cpu-> 120-> 1080-> back to res This is assuming ether a bay or cylinder at the bottom of the case. 240mm rad on the top and 120mm in the back, that would give the computer a good counterclockwise flow in the system.
You dont need to separate loops one is just fine. You will need a 240mm for the cpu at a minimum and then 120 for the 1080. Order of the loop doesnt mater, after about 20-30min of gaming your water temps will stabilize, its more of flow that your going to be concerned about. You dont want to go from the bottom of the case to the top back to the bottom multiple times.

Depending on your case layout i would go res-> pump-> 240-> cpu-> 120-> 1080-> back to res This is assuming ether a bay or cylinder at the bottom of the case. 240mm rad on the top and 120mm in the back, that would give the computer a good counterclockwise flow in the system.
 
Solution
Its doable, I ran a 3 loop system back in the day. 2 Danger Den black ice Extreme 480mm radiators, 1 for the cpu and 1 for dual 580's. then a 240mm radiator for the motherboard waterblock. Case looked like a mess with all the extra tubes running around with 3 cylinder res and 3 pumps.

i7 950 ran at 4.9Ghz 580's ran @ 1005core 2350mem with a voltage mod bios, case ran 20 vantec tornado fans and sounded like a jet engine.