Hey there, @Birdhouseman104!
In addition to what @smorizio mentioned, I'd advise you to check all the connections inside your PC rig and make sure that both the CD-ROM and your WD Blue HDD are properly mounted inside. There shouldn't be any loose screws as they could cause extra vibration which leads to these strange noises. However, you should better be safe than sorry and back up all your important files from the WD Blue somewhere off-site and make sure that you have a duplicate of the files elsewhere to avoid any potential data loss. If reseating the connections and the hardware doesn't help with the noises, let us know. You mentioned that it happens only when there's a disk in the CD-ROM, right? If you have access to another working PC, you could try putting the CD-ROM there and check how it would perform.
Keep us posted.
SuperSoph_WD