As a general rule of thumb, don't run DDR3 slower than 1600MHz CL9. If you have 1333MHz DDR3, make sure it's CL7. Now that DDR3 production is mature, you can often find much faster RAM than that for a good price. Did you purchase the RAM already?
In regards to bottlenecking though, it all depends on the application. RAM is rarely a primary bottleneck. What applications are you worried about bottlenecking?