IF it works together, it will have to run on the highest common frequency and highest timings. You should first get JEDEC timings from one set and then the other, then set it to 1333MHz (it's 667MHz in real, double data rate) with highest timings on this frequency (ie. if one module is CL7 and other CL9, you need to use CL9).
There is always risk they just won't work together, but your frequencies and DDR3 are rather low/old so the chances are quite decent. Also check your motherboard to use suggested RAM slots, it might help. In case of issues, check out whether there is a newer BIOS improving RAM compatibility/stability.
Strongly depending on the use case your system performance may go up but also down, you need to test it out to figure out whether you are suffering on RAM capacity or RAM throughput.
... And, make sure both old and new RAM modules run with same voltage!