For a modern GPU all that really matters is if the motherboard has a PCI-e x16 slot, there is physically enough space in the case to fit the card, there is sufficient airflow and the PSU provides enough power. All I can say for certain is that your motherboard is compatible. As I don't know your case or PSU. I don't know if they are compatible. Althoug they most likely are unless you have a 250W PSU and a Small Form Factor case.