Yes by A LOT. It really depends on the program though. Some games like WoW, League of legends, and other MMO/MOBA type games will let you use a slider to put a limiter on your frames, some games do it automatically, such as Bethesda games, and some games you have to use vertical sync if you want to limit your framerate.
For exampe if I were to turn my frame limit off on WoW, it would constantly be trying to push higher than what it needs to and it will overheat quickly due to it trying to push as hard as it can, If you don't limit a GPU that's usually what it does, There are a few instances where the game is actually pushed to the max, but usually the GPU will try to push the highest framerate it can and will heat up a lot faster...