Endlessone123 stated :
If the ram can fit snuggly into the ram slots with the clips on the sides closed then it is most likely compatible
well I beg to differ, if the ram in his hands is 2133 and the board only support 2400 and higher, it wont run at all.
your generalization is at best a " try it and see" attitude that lands so many people on this forum seeking help.
a7dfj8aerj :
your user manual is located at :https://www.manualslib.com/manual/868577/Asus-Rampage-V-Extreme.html
Yo0u failed to mention what make/model speed your ram is, so I cannot answer your questions
but I can point the page of specifications of your motherboard and states the memory requirements
https://www.manualslib.com/manual/868577/Asus-Rampage-V-Extreme.html?page=10#manual
also checked your CPU as you will have noticed your motherboard can do a lot of Overclocked speeds BUT it is dependent on your CPU abilities
Now looking more closely to the I7-5930K we find on this web page
https://ark.intel.com/products/82931/Intel-Core-i7-5930K-Processor-15M-Cache-up-to-3_70-GHz the memory specifications and sorry but seems you are limited to using DDR4 1333/1600/2133 only.
hope that answers your question