Do you mean a Low Profile DIMMs ?
A Low Profile memory is a half height full-pcb common memory stick, it looks smaller than common memory stick but comes with the same capacity as a common memory sticks. So yeah, if you a referring to a Low Profile memory, then yes, it would work perfectly, as long as your system supports it. For general use, such as Office and Browsing the web, a low profile memory sticks doesn't make any difference and still safe as well. but for gaming, heavy load system, and memory intensive tasks, i would recommend getting a better memory sticks with full pcb design and a heat spreader, in case you're using it for a long period of time.