Not much problem with compatibilities between a GPU and a motherboard these days. Any motherboard with a PCIe x16 slot should be able to support any GPU's out there (as all are plugged in a PCIe x16 slot).
I'd be more concerned about the GPU's compatibilitiy with the 1) CPU (in case you chose a weak CPU that might bottleneck the powerful GPU), 2) PSU (the power draw of the GPU and other components as well as the number of 6-pin or 8-pin connectors), 3) Case (the length clearance allowed by the chassis you choose), and 4) Monitor (a powerful GPU deserves a fast/high res monitor).