From the EBuyer website:
Asus Intel PRIME B250M-K LGA 1151
Memory
2 x DIMMs, maximum 32 GB, DDR4 2400*/ 2133**MHz, non-ECC, un-buffered memory
Dual channel memory architecture
Supports Intel® Extreme Memory Profile (XMP)
* Due to Intel® chipset limitation, DDR4 2400MHz memory frequency is only supported by 7th Generation Intel® processors. Higher memory modules will run at the maximum transfer rate of DDR4 2400MHz.
** Due to Intel® chipset limitation, DDR4 2133MHz and higher memory modules on 6th Generation Intel® processors will run at the maximum transfer rate of DDR4 2133MHz.
http://www.ebuyer.com/769603-asus-intel-prime-b250m-k-lga-1151-matx-motherboard-prime-b250m-k
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As there are 2 slots then I see no reason why this should not work.
However it is my understanding that DDR4 2300 MHz is actually PC-17000