Usb randomly stops working while my computer is on

Melt Man

Commendable
Dec 30, 2016
9
0
1,510
Whenever I am using my computer, my usb randomly stops working and it won't work again until I reboot. I have updated all of my drivers for my mouse and keyboard, and for my motherboard. (Asus 970 pro gaming/aura)

I went into bios and tried changing it to and from legacy usb and that didn't seem to fix it either. Thanks in advance for the help, if you need any other info I can definitely provide it.

Edit: this started happening after I installed a new motherboard. Whenever it happens the sound that is coming through also gets very distorted and glitchy. And it can happen anywhere from 10 minutes of being on to a few days after it's been running so it's seemingly random. Also, it's happened when I was playing games and also when I wasn't so I don't think it's that. I've also tested the keyboard and mouse on another computer and they work fine.
 

Melt Man

Commendable
Dec 30, 2016
9
0
1,510
I apologize, I forgot to mention I got a new motherboard after fixing a previous problem where my computer wouldn't boot, which was fixed by unplugging a cord that was plugged into the fan that didn't need to be there.

And it's been doing that ever since I installed the new motherboard.