boosted1g :
Ram is designed to work in pairs so 2x4gb is real world 10-16% faster than 1x8gb.
Dual channel only achieves 10%-16% better performance in memory benchmarks.
In real-world use, a 0%-3% speedup is more typical. So it's not something you usually need to worry about unless you do tasks which require lots of memory-intensive calculations (computer simulations), or play games on integrated video (which uses your RAM as VRAM).
http://www.hardwaresecrets.com/does-dual-channel-memory-make-difference-in-gaming-performance/7/
http://www.gamersnexus.net/guides/1349-ram-how-dual-channel-works-vs-single-channel/Page-3
Get the 2x4GB if you can (it's "free" performance). But if you get the 1x8GB (maybe you plan to upgrade to 2x8GB in the future), don't worry about it. You're losing an imperceptible amount of performance while you're running on the single stick.
Back in the Core 2 Duo days, I accidentally installed two memory sticks in non-dual channel slots (the pairs are usually color-coded). I noticed the mistake a year later and moved a stick to the correct slot. I excitedly turned the computer on, started a game, and noticed absolutely no difference.