It'll work fine but I don't see why you should CF RX 460's when there's a single RX 480 which has lower theoretical power but trust me - multi GPU is a chore. Unless you already own one, just go with a strong single card. I'd also suggest Intel Pentium G4560 if you don't already have the CPU either, but don't fret if you own it - an OC'd FX can still hold it's ground in gaming.