the driver folder is just a folder with the drivers before they are installed on the pc, the folder is not used after you install then into windows folders and windows registry uses the installed drivers
if you plan to migrate a hard disk with a install in it, before doing the swithc i would uninstall sound card drivers, chipset drivers, network drivers and turn pc off
do the mainboard migration and if windows is cooperative and oots with the new mainboard, install new drivers for the components that windows doesn't install by itself
the install drivers folder you mention, wipe them, those folders are just useless now that you are going to change mainboard