Each module has a 64-bit data path. In dual channel mode the two 64-bit data paths appear to work as one 128-bit data path. So each read or write happens 128 bits at a time. In single channel mode only 64 bits can be read/written at a time.
Technically speaking, the speed doesn't change. But the effective speed does change because twice as much data is being processed in the same amount of time. That's why I said "...so, in effect, it will be running at half speed"
BTW, "Avexir Core Series 8GB 288-Pin DDR4 SDRAM DDR4 2400" is NOT 2400MHz. You won't see them put the "MHz" behind the 2400. Its clock speed will be 1200MHz but they advertise it as "2400" because, being DDR (double data rate), it will handle reads or writes on both the rising edge and the falling edge of the clock cycle. That's purely a marketing ploy. Check it out in the Memory tab of CPU-Z and you'll see the actual speed.
http://www.hardwaresecrets.com/everything-you-need-to-know-about-the-dual-triple-and-quad-channel-memory-architectures/2/
With 64 bits per channel, i.e. physical socket, there is no way to run part of the memory on a module as dual channel and part as single channel. Either the two sockets run in dual channel mode or they don't. In the case of mixed memory, they won't run in dual channel mode.
http://www.hardwaresecrets.com/memory-upgrade/