can you run two different GPU at the same time, gtx 480 or 660ti for regual games and Ati 5450 for MAME games

NoahJames57

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May 20, 2017
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I have a MAME cabnit and i need 15khz so i use a arcadevga 5000 which is a 5450 from ati. it is not powerful enough to run some of the emulators i want. So i wasnted to know if its possible to have another card in my other PCI slot that is a more powerful card and when i want to use the more powerful emulators i would turn off the arcade monitor and use a regular monitor using my more powerful GPU to run the emulators on that screen. have a gtx 480 and a 660ti. gigabyte p55 ud3 intel 760.
 
MERGED QUESTION
Question from NoahJames57 : "can you run two different cards at the same time, gtx 480 ati 5450 for MAME and regular games"