I can't guarantee that they will be compatible without errors or even work at all, but it might. If it does, note the 1600 MHz kit will run at 1333 MHz kit this is the same for any RAM mismatching you do, all the sticks will run at the same speed as the slowest. In general i recommend trying to use as similar RAM as possible when mix-matching so for example 2 of the same brand, model, speed and latency but that doesn't mean any other combos won't work. Just for reference i know someone running 2x2GB 1333 MHz Corsair DDR3 and 2x2GB 1600 MHz Kingston DDR3 and it works fine but of course both at 1333 MHz and so far he hasn't had any issues so hopefully you will have the same. Hope this helps