Yes, the B250 is the complimentary mobo for a 7th gen cpu like the G4560. Yes it'll work straight out of the box without any motherboard drivers. Yes, you should load the motherboard drivers, windows drivers are generic so don't allow best performance. Yes, after windows is fully updated you should then flash the bios to the latest revision as it'll have tweaks etc for working with the newer versions of Windows OS. Yes, you should also update any and all motherboard drivers too.