Let's try to filter the selection. As far as your 64GB mem cap requirement and an Intel i7 CPU, you are still looking at A LOT of motherboards with 4x RAM slots that support Intel CPUs.
Q#1: Size of motherboard
Are you looking at an ATX-sized or an mATX-sized motherboard? The size of your case plays a major consideration in this selection. If your case is ATX, then either an ATX or an mATX mobo can fit. If you're looking at a smaller mATX case, then it narrows down your mobo options to an mATX one.
Q#2: CPU and Overclocking intentions
This is also related to your choice of an i7 CPU. Best consumer i7 today is the i7-7700K, which is an unlocked ("K") CPU that is best paired with an Intel Z270 chipset motherboard that supports OC'ing. If you don't intend to overclock, the locked (non-"K") i7-7700 is the best consumer i7, which is logically paired with a non OC'able mobo such as the B250- or H270-chipset mobo.
Q#3: Multi-GPU (AMD or Nvidia) or single-GPU (any) setup
This pertains to the number of PCIe x16 slots your motherboard needs. If you are only going to use a single GPU, then, no problems, as all motherboards would have at least 1x PCIe x16 slot. If you are looking at a multi-GPU setup, you need to decide if you want an AMD or an Nvidia GPU. Multi-GPU AMD setups use AMD CrossFire; multi-GPU Nvidia setups use Nvidia SLI. Both need at least 2x PCIe x16 slots with different PCIe lane minimum requirements, x16/x4 speeds for AMD and x8/x8 speeds for Nvidia.
Q#4: Aesthetics and board layout
Some prefer to match color-theme parts in their rig. It's a subjective choice. Do you require that parts in your rig will match a certain motif? Layout of the motherboard and detailed features such as how the SATA ports are oriented/located (for cable routing), actual dimensions of the motherboard, location of ports/headers, and inclusion of shrouds/shields and RGB lighting may come into play.
Q#5: Number of Fan Headers
Not really critical as you can run off some fans in a single header or a fan hub, but, if you prefer that all your case fans/pump run off the motherboard, you might want to consider this factor.
Q#6: Case front panel headers (usually the internal USB version and quantity needed)
Depending on your case's front USB headers, some motherboards have limited amount of USB3.0 or USB2.0 internal headers. To avoid buying extensions/adapters, you might want to consider how many front panel ports you may need to be enabled as these ports will use up the mobo's internal headers. You also want to consider some components that you have that might require such USB internal header connections (some AIO coolers or RGB LED control boxes usually needs USB connections to communicate with the PC/via software).
Q#7: Other required ports/connections
How many rear panel ports (such as USB and Audio jack) do you need? Do you require an on-board Wi-Fi? Do you need dual LAN ports? Will you be using the integrated graphics alongside the dedicated GPU?
Q#8: Budget and buying location
How much is your budget for this motherboard? Where will you be purchasing this item from (certain store, certain website, or general location)?
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