Yes, you'll have the option to repartition and format the drive during the Windows install.
Early on you'll see a screen asking you which drive/partition you wish to install on, delete all those shown. Now you have a choice, you can either use the drive as a single massive partition or divide it into two or more smaller partitions, each partition will be treated as a separate drive and assigned a separate drive letter once Windows is fully installed and running. Your choice but it's easier to just set up one big partition and format it at this stage. Whatever you do, the Windows install will add reserved partitions during the format, it's normal, indeed essential so don't delete them!
If there is another drive in the system, be sure to disconnect it BEFORE you do this, that way all the data/files will be protected from accidental erasure.