Yes, that is what I do. I have my default sound device set as my speakers, than I set my voice app (teamspeak) to output sound to my headset, discord should have the same ability in its options. However it is worth noting I am using a USB headset so it registers as a different sound device, something plugged into the 3.5mm jacks on the PC will not work if the speakers are also using them. You would need another sound card.