NO
Uses socket 775 which pre-dates the i3/i5/i7 series CPUs.
Best CPU it can handle depends on the motherboard in it, what its max tdp is, as well as what CPUs the bios supports.
Rule of thumb is it supports the best CPU dell released with it from the factory.
I can tell you that if you already have a core2duo then a core2quad wont make much fo a difference.
Its like upgrading from 12% to 16%