I would say that GTA V on that graphics card and CPU @720p would run on low-medium settings @ 40fps. The only way to know for sure is to try, however that R7 250 is not a good graphics card for running modern games. Id recommend a GTX 1050ti. That will give you the biggest bang for your buck. After that you may want to think about upgrading to a 3rd gen i5 or i7 for more CPU intensive games.