Okay let's take a step back
1) you have 8GB of RAM installed based on RM (Resource Monitor)
2) Almost every board has video built on, so right off the bat based on your UEFI/BIOS setting that will reduce it by about 1256 (1.2GB) RAM to set aside for video display. If you did reduce it down to 256MB, that will help, but if you just disabled it the RAM is still used because your CPU has the GPU built in (Normal for iCore, APU, etc.)
3) As noted in my previous post the top 3 programs running FireFox + BitDefender + Desktop Window Manager is almost another 1GB
4) Then add in all the other little things like like your desktop, running the NVidia Apps, etc. basically "Make Windows RUN" is unfortunately in a constant state of flux. So while that would make up another 1 1/2GB to as much as 3GB just to run the OS and all the 'apps' (especially if the computer is actively running BACKGROUND HIDDEN programs NOT listed). Some also spike and drop as their timer hits for say check weather for the desktop APP, or scan for NEW updates for STEAM hidden in your tray, and so on.
So that explains the amount of RAM actually 'used' "High load on memory but no applications open" .
Now to further explain why it says "80%" on TM but on RM showing about 50% used (easy to do these days) is if you didn't click on VIEW and change the UPDATE SPEED to HIGH. If it is set on anything else it will 'delay' between what it calculates as compared to what is happening at that moment. So 15 seconds ago when you snapped this screen it may spiked to 80%, but then once it was done saving the image TM would drop down to show 50% usage.
As I demonstrated how 3533MB is in use, if you still feel there it shouldn't be using that much RAM, do some basics:
1) RUN MALWAREBYTES. Antivirus systems don't 'see' Malware.
2) Turn off all the 'apps' in your System Tray in the bottom right corner
3) Turn off any unneeded apps from booting, like for example Adobe launches and repeatedly will keep checking for updates, just as much as JaVa, Steam, Nvidia... so on and so forth and adds up