First, get that clock speed lowered. The 5820K isn't the best overclocker from that line and you're already pushing voltage a little on the high side (by some people's standards). The lowest end CPUs on X99 (5820K and 6800K) tend to not OC as well as the more expensive CPUs in those lines. Many people try to avoid going over 1.3v. Frankly, there's no real world need to sit at 4.5. You're also running hot.
First off, a couple quick settings that can make a big difference:
1) Input voltage. Find this setting and get it to 1.9v. This can make a HUGE difference.
2) LLC: Best setting for this depends on your motherboard. Asus boards tend to actually add voltage when setting this to high/level 1, some other boards will simply ensure that the voltage sticks at what you've set your vCore to when under load.
I'd personally jump your clock down to 4.4GHz and keep your core voltage at 1.3v, plus the two settings above, and see how it runs. Still, at those settings, install & run ROG Realbench Stress Test for an hour & verify your temps are not getting close to 90c and that its stable. That tool is quite sensitive to instability so its a good one to test real world stability. IF that's stable, try gaming for stability. IF gaming is stable at that point, try backing your vCore down to 1.28v and perform both tests again. That should help bring temps down a little. Keep decreasing voltage until you find one that's not stable and add .01v until you're stable. That's the game.