Technically you can, but listen to jankerson, or you'll need to first create a few partitions, move the Page and settings Files and then spend 3 hours on the registry and you'll have a 50/50 chance it will work. This is one of those, just because you may be able to do something does not mean you should.
That being said, you said something that has me puzzled stefangorski02.
When I read your post, I assumed your objective was simply to create a setup (which many do), where their OS AND APPS) are on an SSD and files on a second drive.
You included games as part of what you wanted to separate the OS from. It business, we install certain Applications on secondary RAID arrays for clients and while it's rather easy to install Apps on a separate drive, if you're only using two SSDs, or worse, one SSD and an HDD, the Apps will run as slow as molasses. Consider what they need to do, I don't think I need to explain it, but when I do that for a build, they are installed on a second HW RAID Card, with an average of 8 SAS or SSDs. That takes care of the speed issue.
Granted, I'm not a gamer. In fact, I had to do rebuilds for all our Workstations, including the one in my home office and the GPU I selected was a GTX 1080 Ti which came with a free game called Destiny 2, the full digital version. I figured, what the heck and installed it. You may need to Login to this Blizzard thing but Destiny 2 is installed on my Drive. I don't know maybe some games run on the Desktop, like the Tor browser does???
There is a better way, use one SSD for both OS, Apps and files, get the right nackup and restore app ($50) and you'll never have any further concerns.
BTW, regarding that Destiny 2 game, the only thing I've been able to get the character I selected to do, is waste lots of ammo. But, WOW, the graphics are amazing. Sorry to digress.
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